Online GPAT Test practice 2018-19

Online GPAT Test practice 2018-19

Quiz

 

1. An 'orphan drug' is:
   1.   A very cheap drug
   2.   A drug which has no therapeutic use
   3.   A drug needed for treatment or prevention of a
      rare disease
   4.   A drug which acts on Orphanin receptors
2. In addition to slow intravenous infusion, which of the following routes of administration allows for titration of
   the dose of a drug with the response:
   1.   Sublingual
   2.   Transdermal
   3.   Inhalational
   4.   Nasal insufflation
3. Which of the following drugs is administered by intranasal spray/application for systemic action:
   1.   Phenylephrine
   2.   Desmopressin
   3.   Azelastine
   4.   Beclomethasone dipropionate
4. Select the route of administration which carries the highest risk of adversely affecting vital functions:
   1.   Intra arterial injection
   2.   Intrathecal injection
   3.   Intravenous injection
   4.   Intramuscular injection
5. Alkalinization of urine hastens the excretion of:
   1.   Weakly basic drugs
   2.   Weakly acidic drugs
   3.   Strong electrolytes
   4.   Nonpolar drugs
6. Majority of drugs cross biological membranes primarily by:
   1.   Passive diffusion
   2.   Facilitated diffusion
   3.   Active transport
   4.   Pinocytosis
7. Which of the following drugs is most likely to be absorbed from the stomach
   1.   Morphine sulfate
   2.   Diclofenac sodium
   3.   Hyoscine hydrobromide
   4.   Quinine dihydrochloride
8. Which of the following is a weakly acidic drug:
   1.   Atropine sulfate
   2.   Chloroquine phosphate
   3.   Ephedrine hydrochloride
   4.   Phenytoin sodium
9. Active transport of a substance across biological membranes has the following characteristics except:
   1.   It is specific
   2.   It is pH dependent
   3.   It is saturable
   4.   It requires metabolic energy
10. Bioavailability of drug refers to:
    1.   Percentage of administered dose that reaches
       systemic circulation in the unchanged form
    2.   Ratio of oral to parenteral dose
    3.   Ratio of orally administered drug to that excreted
       in the faeces
    4.   Ratio of drug excreted unchanged in urine to
       that excreted as metabolites
11. Tricyclic antidepressants can alter the oral absorption of many drugs by:
    1.   Complexing with the other drug in the intestinal
       lumen
    2.   Altering gut motility
    3.   Altering gut flora
    4.   Damaging gut mucosa
12. A prototype is-
    1.   Main member of a class of drugs
    2.   The oldest member of a class of drugs
    3.   An inactive drug that is transformed in the
       body to an active metabolite
    4.   A drug that is stored in body tissues and is then
       gradually released in the circulation
13. A prodrug is:
    1.   The prototype member of a class of drugs
    2.   The oldest member of a class of drugs
    3.   An inactive drug that is transformed in the
       body to an active metabolite
    4.   A drug that is stored in body tissues and is then
       gradually released in the circulation
14. Which of the following is a prodrug
    1.   Hydralazine
    2.   Clonidine
    3.   Captopril
    4.   Enalapril
15. The most commonly occurring conjugation reaction for drugs and their metabolites is:
    1.   Glucuronidation
    2.   Acetylation
    3.   Methylation
    4.   Glutathione conjugation
16. Microsomal enzyme induction can be a cause of:
    1.   Tolerance
    2.   Physical dependence
    3.   Psychological dependence
    4.   Idiosyncrasy
17. The following drug metabolizing reaction is entirely nonmicrosomal:
    1.   Glucuronide conjugation
    2.   Acetylation
    3.   Oxidation
    4.   Reduction
18. Select the drug that undergoes extensive first-pass metabolism in the liver:
    1.   Phenobarbitone
    2.   Propranolol
    3.   Phenylbutazone
    4.   Theophylline
19. Drugs which undergo high degree of first-pass metabolism in liver:
    1.   Have low oral bioavailability
    2.   Are excreted primarily in bile
    3.   Are contraindicated in liver disease
    4.   Exhibit zero order kinetics of elimination
20. Glomerular filtration of a drug is affected by its:
    1.   Lipid solubility
    2.   Plasma protein binding
    3.   Degree of ionization
    4.   Rate of tubular secretion